Strongest pain relief cream without a prescription. This odorless and greaseless cream temporarily provides warming relief of minor aches and pains of muscles and joints of the body. Zostrix cream is perfect for treating arthritis pain with a triple-strength formula. Zostrix can be used alone to reduce arthritis pain, or for additional pain relief when used along with oral pain medications. Zostrix contains a powerful natural pain reliever derived from red hot chili peppers called capsaicin.